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Left ventricular morphologic features and function in nonhospitalized cocaine users: a quantitative two-dimensional echocardiographic study.

M J Eisenberg·J Jue·J Mendelson·R T Jones·N B Schiller
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Abstract

To determine whether left ventricular (LV) hypertrophy or dysfunction is present in nonhospitalized cocaine users, we performed quantitative two-dimensional echocardiography in 20 intravenous cocaine users and 20 age- and sex-matched controls. Cocaine users were normotensive, had begun taking cocaine an average of 14 years earlier, and had used cocaine an average of 8 times/mo during the preceding year. There were no significant differences between cocaine users and control subjects for LV mass index (79 vs 74 gm/m2, respectively), mean wall thickness (0.95 vs 0.91 cm), end-diastolic volume index (55 vs 56 ml/m2), end-systolic volume index (17 vs 19 ml/m2), or ejection fraction (70 vs 66%; p > or = 0.09 for all comparisons). Moreover, none of the cocaine users or control subjects had significant regional wall motion abnormalities, and none of the subjects or controls had ejection fractions < 55%. Thus we found little evidence that significant LV hypertrophy or dysfunction is present in nonhospitalized cocaine users. From these results we speculate that cocaine-associated LV hypertrophy and dysfunction may be restricted to certain high-risk groups of chronic cocaine users.

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AdultChronic DiseaseCocaineEchocardiographyFemaleHeart VentriclesHumansHypertrophy, Left VentricularMaleSubstance-Related DisordersVentricular Function, LeftComparative StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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M J Eisenberg, J Jue, J Mendelson, R T Jones, N B Schiller. 1995. Left ventricular morphologic features and function in nonhospitalized cocaine users: a quantitative two-dimensional echocardiographic study.. https://doi.org/10.1016/0002-8703(95)90115-9

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