c-fos expression in central cardiovascular pathways.

J B Minson; S Suzuki; I J Llewellyn-Smith; P M Pilowsky; L F Arnolda; J P Chalmers

doi:10.3109/10641969509087055

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c-fos expression in central cardiovascular pathways.

J B Minson·S Suzuki·I J Llewellyn-Smith·P M Pilowsky·L F Arnolda·J P Chalmers

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Abstract

Injection of muscimol in the caudal ventrolateral medulla increases blood pressure and stimulates neuronal c-fos expression in the rostral ventral medulla (RVM). The blockade of c-fos expression in the RVM by antisense oligonucleotides attenuates the blood pressure response to this muscimol-induced disinhibition of the RVM and also reduces resting blood pressure. The results suggest that cardiovascular neurons in the RVM express c-fos and that the basal and stimulated expression of the c-fos gene is important in the central regulation of blood pressure.

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Animals Base Sequence Blood Pressure Cardiovascular Physiological Phenomena Cardiovascular System Gene Expression Genes, fos Immunohistochemistry Male Medulla Oblongata Molecular Sequence Data Muscimol Neural Pathways Oligonucleotides, Antisense RNA, Messenger Rats Rats, Inbred WKY Journal Article Research Support, Non-U.S. Gov't

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J B Minson, S Suzuki, I J Llewellyn-Smith, P M Pilowsky, L F Arnolda, J P Chalmers. c-fos expression in central cardiovascular pathways.. https://doi.org/10.3109/10641969509087055

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