PubMed HealthSearch

PubMed · 7739366

A matched filter echo summation technique for MRI.

Abstract

A technique is presented to increase the signal-to-noise ratio (SNR) in two-dimensional (2D), phase-encoded imaging at low SNR. The essence of this technique is to combine multiple echoes in the time domain. As analyzed in the paper, phase discrepancies exist among different echoes and may deteriorate the combined echo. In particular, extraneous phase shifts can be created if unshielded gradient coils are used. To overcome these phase discrepancies, a matched filter was derived from the k = 0 component of image. This matched filter has the same phase discrepancies among its echoes as the imaging signal and its magnitude decays with an average T2. In the echo summation with the matched filter, the phase of the matched filter was subtracted from the imaging signal and the magnitude of the matched filter was used as the weighting function. We have shown that this matched filter echo summation technique has better SNR than the case of 2D, phase-encoded imaging in both simulation and experiment. The SNR improvement is up to 60% in a phantom experiment. This technique is mostly useful in low SNR imaging that requires long imaging time, such as spectroscopic imaging and 19F imaging.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

D Lu, P M Joseph. 1995. A matched filter echo summation technique for MRI.. https://doi.org/10.1016/0730-725x(94)00110-o

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Global Genomic Surveillance.

Global genomic surveillance has emerged as a foundational pillar of public health in the twenty-first century, enabling real-time tracking of pathogen evolution and informing outbreak response. This chapter examines the strategic architecture of global genomic surveillance, focusing on its application to arboviruses such as chikungunya virus (CHIKV). It explores the integration of genomic data with epidemiological, clinical, and environmental information within a One Health framework, while addressing critical challenges in governance, equity, and interoperability. The discussion covers the entire genomic surveillance workflow, from sample collection and sequencing to bioinformatic analysis and phylogenetic inference, and highlights the transformative role of artificial intelligence (AI) in predictive surveillance. By analyzing global initiatives, operational barriers, and emerging technologies, this chapter underscores the necessity of sustainable, equitable, and interoperable genomic systems to proactively address current and future infectious disease threats.

Humans

Systematic Dissection of Key Driver Perturbation Signatures in Single Cells via ECCITE-seq.

CRISPR screens, such as expanded CRISPR-compatible cellular indexing of transcriptomes and epitopes by sequencing (ECCITE-seq), enable the simultaneous measurement of transcriptomes, gRNA identity, and cell-surface protein expression at single-cell resolution to systematically interrogate gene function. This platform provides a powerful and scalable experimental approach for validating disease-associated regulators identified by large-scale association studies and other computational methods, including network-based analyses of multi-omics data. Here, as an example application, we describe an ECCITE-seq framework to characterize the transcriptomic consequences of perturbing multiple neuronal key driver genes associated with Alzheimer's disease (AD) in human-induced pluripotent stem cell (hiPSC)-derived neurons. More broadly, by integrating customized pooled gRNA libraries with different CRISPR effectors across multiple cell types, this approach allows for the assessment of the regulatory impact of candidate genes implicated in development and disease processes.

Humans

Identification of Genome-Wide Chromatin Structural Aberration in Cancer by Hi-C Analysis.

Aberrant three-dimensional genome organization is a hallmark of cancer, often driving oncogene activation through mechanisms such as enhancer hijacking. High-throughput chromosome conformation capture (Hi-C) maps these interactions on a genome-wide scale. Unlike earlier dilution-based methods, in situ Hi-C performs proximity ligation within intact nuclei, minimizing random ligation noise and enabling fine-scale structure detection. This chapter describes an optimized in situ Hi-C protocol tailored for cancer cell lines using MboI digestion and biotin-mediated pull-down to generate high-complexity libraries. We further outline a computational workflow that extends beyond standard topological mapping of compartments and topologically associating domains to identify cancer-specific aberrations. Specifically, we focus on detecting chromosomal rearrangements (structural variants) and characterizing the distinct circular topology of extrachromosomal DNA. This integrated experimental and analytical framework provides the necessary tools to dissect the spatial dysregulation underlying tumor evolution.

Humans