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PubMed · 7742607

[Method for evaluating long term complications. A study from a phase III trial comparing two low dose rates in gynecologic brachytherapy].

R Lancar·A Kramar·C Haie-Meder·P Lambin·J Bouzy·P Scalliet·A Gerbaulet
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Abstract

When treatment complications are the main criteria of a study, the simplest way for estimating the complication rate over time is to use the Kaplan-Meier method. The failure is the onset of the first complication. A new way is proposed here which takes into account the time to an eventual second, and third complication, and their duration as well. Results from a phase III randomized trial comparing two preoperative brachytherapy low dose rates in localized stage cervix carcinoma patients are used to illustrate both methods. The new method showed a greater long term complication rate in the higher dose rate group.

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BrachytherapyCross-Sectional StudiesDose-Response Relationship, RadiationFemaleFollow-Up StudiesHumansNeoplasm StagingRadiation InjuriesRadiotherapy DosageRisk FactorsSurvival AnalysisUterine Cervical NeoplasmsClinical TrialClinical Trial, Phase IIIEnglish AbstractJournal ArticleRandomized Controlled Trial

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R Lancar, A Kramar, C Haie-Meder, P Lambin, J Bouzy, P Scalliet, A Gerbaulet. 1994. [Method for evaluating long term complications. A study from a phase III trial comparing two low dose rates in gynecologic brachytherapy].. https://pubmed.ncbi.nlm.nih.gov/7742607/

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PubMed1998

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