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PubMed · 775054

Antimalarials V: aminobenzothiazoles.

E R Atkinson·F E Granchelli
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Abstract

Four mono- and dialkylated 4-aminobenzothiazoles (VII-X) were prepared as analogs of potent causal prophylactic drugs in the 8-aminoquinoline series. Compounds VII and VIII were toxic at 80 mg/kg in the chick; IX was inactive at 640 mg/kg. In a sporozoite-induced mouse test system, X was inactive at 30 mg/kg and toxic at 480 mg/kg. None of the compounds was active as a suppressive drug.

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AnimalsAntimalarialsChickensMalariaMethodsMicePlasmodium bergheiThiazolesJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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E R Atkinson, F E Granchelli. 1976. Antimalarials V: aminobenzothiazoles.. https://doi.org/10.1002/jps.2600650440

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