Actin-based bacterial motility.

P Cossart

doi:10.1016/0955-0674(95)80050-6

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PubMed · 7755995

Actin-based bacterial motility.

P Cossart

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Abstract

Listeria monocytogenes and other bacterial pathogens move in the host cell cytoplasm, propelled by continuous actin assembly at one pole of the bacterium. This actin-based motility requires the presence of the bacterial proteins ActA on L. monocytogenes and IcsA on Shigella flexneri. There have been several major discoveries in the past year: the discovery of the polar distribution of ActA and IcsA on the bacterial surface; the demonstration that bacterial ActA is phosphorylated in infected host cells; the involvement of some host cell proteins, particularly profilin; and the dramatic effect of ActA expression in transfected eukaryotic cells. A cell-free system that reconstitutes faithfully the actin-based motility of L. monocytogenes promises to be instrumental in the further dissection of this fascinating phenomenon.

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Actins Amino Acid Sequence Bacterial Proteins Cell Movement DNA-Binding Proteins Listeria monocytogenes Membrane Proteins Molecular Sequence Data Shigella flexneri Transcription Factors Journal Article Research Support, Non-U.S. Gov't Review

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P Cossart. 1995. Actin-based bacterial motility.. https://doi.org/10.1016/0955-0674(95)80050-6

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