Fibroblasts as efficient antigen-presenting cells in lymphoid organs.

T M Kündig; M F Bachmann; C DiPaolo; J J Simard; M Battegay; H Lother; A Gessner; K Kühlcke; P S Ohashi; H Hengartner

doi:10.1126/science.7761853

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PubMed · 7761853

Fibroblasts as efficient antigen-presenting cells in lymphoid organs.

T M Kündig·M F Bachmann·C DiPaolo·J J Simard·M Battegay·H Lother·A Gessner·K Kühlcke·P S Ohashi·H Hengartner

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Abstract

Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.

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Animals Antigen-Presenting Cells Cytotoxicity, Immunologic Fibroblasts Glycoproteins Histocompatibility Antigens Class I L Cells Lymphocytic Choriomeningitis Lymphocytic choriomeningitis virus Lymphoid Tissue Mice Mice, Inbred C57BL Neoplasms T-Lymphocytes, Cytotoxic Transfection Tumor Cells, Cultured Viral Proteins Journal Article Research Support, Non-U.S. Gov't

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T M Kündig, M F Bachmann, C DiPaolo, J J Simard, M Battegay, H Lother, A Gessner, K Kühlcke, P S Ohashi, H Hengartner. 1995-06-02. Fibroblasts as efficient antigen-presenting cells in lymphoid organs.. https://doi.org/10.1126/science.7761853

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