New programs for protein tertiary structure prediction.

J S Fetrow; S H Bryant

doi:10.1038/nbt0493-479

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New programs for protein tertiary structure prediction.

J S Fetrow·S H Bryant

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Abstract

Prediction of protein tertiary structure remains an unsolved problem in molecular biology, but a solution to this problem is extremely important for protein engineering and rational drug design. Recent developments in motif recognition and side chain modeling present the prospect of nearly automatic model building for a large fraction of newly determined protein sequences. We review some of these new algorithms and present preliminary results of their application to the prediction of a structure for fasciclin III, a neural adhesion molecule from Drosophila.

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Animals Cell Adhesion Molecules, Neuronal Drosophila Drosophila Proteins Drug Design Models, Molecular Protein Engineering Protein Structure, Tertiary Journal Article Review

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J S Fetrow, S H Bryant. 1993. New programs for protein tertiary structure prediction.. https://doi.org/10.1038/nbt0493-479

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