Engineering bispecific antibodies.

P Holliger; G Winter

doi:10.1016/0958-1669(93)90010-t

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Engineering bispecific antibodies.

P Holliger·G Winter

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Abstract

Bispecific antibodies have immense potential as reagents and in medicine. Until recently, they were made by combining monoclonal antibodies of two different specificities in vitro, or by fusion of the corresponding hybridomas. Protein engineering now offers the chance to construct a range of small 'designer' bispecific antibodies using antibody fragments as building blocks.

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Animals Antibodies Biotechnology Drug Design Protein Engineering Journal Article Research Support, Non-U.S. Gov't Review

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P Holliger, G Winter. 1993. Engineering bispecific antibodies.. https://doi.org/10.1016/0958-1669(93)90010-t

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