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Suboptimal control of fed-batch bioprocesses using phase properties.

A Diener·B Goldschmidt
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Abstract

A new method for the evaluation of suboptimal feeding strategies for fed-batch bioprocesses is introduced. This method is based on a time-local optimization of the process dynamics. To include global effects into the optimization, the process has to be partitioned into several phases with different local extremality conditions. The penicillin bioprocess is used to illustrate the method. One advantage of the proposed method is that the evaluated control function appears as a feedback law. Simultaneously, the new method allows the inclusion of constraints on the process states and the use of very complex models. Due to the simplicity and stability of the numerical procedure the method is robust against external perturbation. Therefore, it is suited for use in on-line controls.

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A Diener, B Goldschmidt. 1994-03-15. Suboptimal control of fed-batch bioprocesses using phase properties.. https://doi.org/10.1016/0168-1656(94)90100-7

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