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PubMed · 7765062

Comparing nucleotide and protein sequences by linguistic methods.

S Pietrokovski
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Abstract

Nucleotide and amino acid sequences can be analyzed and compared by their oligomer compositions. Such methods are fundamentally different from comparison methods based on sequence alignment. They are analogous to the linguistic analysis of human texts. The methods have a wide range of sensitivity and can identify homologous as well as functionally and taxonomically related sequences. Significant sequence dissimilarity can also be identified enabling detection of foreign DNA sequences in genomes, genetic libraries and databases. The simplicity and speed of linguistic methods make them very suitable for database searching and maintenance and as a preliminary step to more specific and time-consuming analysis methods.

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Amino Acid SequenceAnimalsBase SequenceBiotechnologyDNA, FungalDNA, MitochondrialDNA, ViralHumansLinguisticsMiceMolecular Sequence DataPromoter Regions, GeneticRatsRetroviridaeSaccharomyces cerevisiaeSequence AlignmentSequence Homology, Amino AcidComparative StudyJournal Article

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S Pietrokovski. 1994-06-30. Comparing nucleotide and protein sequences by linguistic methods.. https://doi.org/10.1016/0168-1656(94)90040-x

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