Antigen-induced conformational changes in antibodies: a problem for structural prediction and design.

R L Stanfield; I A Wilson

doi:10.1016/0167-7799(94)90139-2

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Antigen-induced conformational changes in antibodies: a problem for structural prediction and design.

R L Stanfield·I A Wilson

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Abstract

Recent work has shown that large conformational changes in antibodies can accompany antigen binding. These structural changes can alter dramatically the size, shape and charge distribution in the antigen-binding pocket, and may present problems for accurate modeling of antibody structures.

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Animals Antibodies Antigens Humans Models, Molecular Protein Conformation Journal Article Review

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R L Stanfield, I A Wilson. 1994. Antigen-induced conformational changes in antibodies: a problem for structural prediction and design.. https://doi.org/10.1016/0167-7799(94)90139-2

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