Cytoskeletal modifications induced by 4-hydroxynonenal.

E Gadoni; A Olivero; A Miglietta; C Bocca; L Gabriel

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PubMed · 7765307

Cytoskeletal modifications induced by 4-hydroxynonenal.

E Gadoni·A Olivero·A Miglietta·C Bocca·L Gabriel

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Abstract

The antiproliferative action of 4-hydroxynonenal (HNE) could be related to an interaction with cytoskeletal structures. In this paper the effects exerted by HNE on microtubules and on microfilaments are examined by immunofluorescence. HNE alters cell morphology causing both the depolymerization of the microtubular structures and the dissolution of the stress-fibres. Taxol protects microtubules, preventing the depolymerizing effect of the aldehyde. The action of HNE could be attributed to its affinity for sulphydryl groups, which are essential in maintaining tubulin and actin both in the polymerized form.

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3T3 Cells Actin Cytoskeleton Actins Aldehydes Animals Biotechnology Cytoskeleton Fluorescent Antibody Technique Mice Microtubules Paclitaxel Tubulin Journal Article

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E Gadoni, A Olivero, A Miglietta, C Bocca, L Gabriel. 1993. Cytoskeletal modifications induced by 4-hydroxynonenal.. https://pubmed.ncbi.nlm.nih.gov/7765307/

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