Studies on low-level MDR cells.

G Belvedere; E Dolfini

doi:10.1007/bf00744667

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PubMed · 7765328

Studies on low-level MDR cells.

G Belvedere·E Dolfini

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Abstract

Acquired or spontaneous resistance is a major clinical problem in the treatment of cancer. Low levels of MDR gene expression or P-glycoprotein have been correlated with a high level of drug resistance in vitro and a poor response to chemotherapy in some tumors. A strong correlation between MDR mRNA, P-glycoprotein levels and degree of drug resistance has not been found in several resistant model tumor cell lines. In some cell lines at low and high level of resistance different mechanisms seem to be involved.

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ATP Binding Cassette Transporter, Subfamily B, Member 1 Antineoplastic Agents Carrier Proteins Cell Line Cell Survival Drug Resistance Gene Expression Humans Membrane Glycoproteins Neoplasms RNA, Messenger Tumor Cells, Cultured Journal Article Review

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G Belvedere, E Dolfini. 1993. Studies on low-level MDR cells.. https://doi.org/10.1007/bf00744667

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