Gene therapy using adenoviral vectors.

B C Trapnell; M Gorziglia

doi:10.1016/0958-1669(94)90084-1

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PubMed · 7765745

Gene therapy using adenoviral vectors.

B C Trapnell·M Gorziglia

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Abstract

Growing interest in adenoviral gene-transfer vectors, stimulated by efforts to develop in vivo gene therapy for cystic fibrosis, has led to an evaluation of their use in many other applications of in vivo gene therapy. Studies are beginning to define strategies for the efficient, albeit transient, expression of the transferred gene and have further identified and partially characterized important host responses to in vivo gene transfer that modulate the duration of expression of the transgene. Ongoing work is actively exploring these issues, with a view to the design of the next generation of adenoviral vectors.

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Adenoviridae Animals Clinical Trials as Topic Cystic Fibrosis Gene Transfer Techniques Genetic Therapy Genetic Vectors Humans Journal Article Review

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B C Trapnell, M Gorziglia. 1994. Gene therapy using adenoviral vectors.. https://doi.org/10.1016/0958-1669(94)90084-1

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