Structure, function and cellular expression of complement anaphylatoxin receptors.

R A Wetsel

doi:10.1016/0952-7915(95)80028-x

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Structure, function and cellular expression of complement anaphylatoxin receptors.

R A Wetsel

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Abstract

The past year has seen significant advances in determining the important structural-functional domains of the complement C5a anaphylatoxin receptor. The current model suggests a two-site binding motif in which part of the amino-terminal extracellular domain of the receptor is recognized first by the amino-terminal end and disulfide-linked core of the C5a ligand. This is followed by interaction of the carboxy-terminal end of C5a with a second, and as yet undefined, site on the receptor that results in activating appropriate signal transduction pathways via receptor coupled G proteins. Another recent advance has been the discovery that the C5a receptor is expressed on non-myeloid cells, suggesting that C5a confers previously unexpected functions on certain target tissue cells, including bronchial and alveolar epithelial cells, hepatocytes, astrocytes, and vascular endothelial cells.

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Amino Acid Sequence Animals Complement Activation Complement C5a Humans Molecular Sequence Data Receptors, Complement Journal Article Review

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R A Wetsel. 1995. Structure, function and cellular expression of complement anaphylatoxin receptors.. https://doi.org/10.1016/0952-7915(95)80028-x

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