Cytokine-binding proteins: stimulating antagonists.

B Klein; H Brailly

doi:10.1016/0167-5699(95)80161-8

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Cytokine-binding proteins: stimulating antagonists.

B Klein·H Brailly

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Abstract

Cytokine-binding proteins (CBPs) block the ability of cytokines to interact with their receptors. These agents can potentially provide a means of treating pathological conditions that have a significant cytokine involvement. However, a major drawback of such approaches relates to the fact that CBPs stabilize the cytokine in the form of a cytokine-CBP complex in vivo. Here, Bernard Klein and Hervé Brailly discuss the possibility that CBPs behave either as agonists or antagonists according to their pharmacokinetic characteristics in vivo, and suggest a mechanism by which stable complexes might be cleared from the system.

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Animals Cytokines Humans Immunosuppressive Agents Multiple Myeloma Protein Binding Receptors, Cytokine Journal Article Review

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B Klein, H Brailly. 1995. Cytokine-binding proteins: stimulating antagonists.. https://doi.org/10.1016/0167-5699(95)80161-8

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