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PubMed · 7785437

[Tyr-D-Ala-Gly-Phe-D-Leu (DADL) solid-phase synthesis and its effects on immune function].

F Zhong·X Y Li·S L Yang
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Abstract

DADL, a delta-receptor selective enkephalin analogue, was prepared with the technique of solid-phase peptide synthesis. It was found to stimulate directly the proliferation of mouse splenic lymphocytes dose-dependently. However, synergistic effect of DADL at different concentrations with ConA and LPS were not found. In addition, TNF-alpha production was increased by ip DADL (1.0 mg.kg-1 x 6 d) in mice and the production of LPS-induced TNF-alpha in mouse peritoneal macrophages was enhanced after DADL was added in vitro. These results suggest that DADL, like enkephalins, exerts some immunoregulatory activities.

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Adjuvants, ImmunologicAnimalsCell DivisionEnkephalin, Leucine-2-AlanineLymphocytesMacrophages, PeritonealMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Opioid, deltaSpleenTumor Necrosis Factor-alphaEnglish AbstractJournal Article

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F Zhong, X Y Li, S L Yang. 1995. [Tyr-D-Ala-Gly-Phe-D-Leu (DADL) solid-phase synthesis and its effects on immune function].. https://pubmed.ncbi.nlm.nih.gov/7785437/

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