Multidrug resistance.

T Tsuruo; A Tomida

doi:10.1097/00001813-199504000-00003

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PubMed · 7795269

Multidrug resistance.

T Tsuruo·A Tomida

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Abstract

Since we found verapamil as a multidrug resistance (MDR) reversing agent in 1981, many MDR reversing compounds have been reported. This type of drug must have strong effects with little side effects. We recently found MS-209 and PSC-833 as reversing agents. These two compounds interacted directly with P-glycoprotein, and showed a good MDR reversing effect in vitro and in vivo. MRK16, an antibody against P-glycoprotein, also showed a good therapeutic effect against drug resistant human tumors. MS-209, PSC-833 and the antibody against P-glycoprotein are interesting candidates for clinical use in the future.

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ATP Binding Cassette Transporter, Subfamily B, Member 1 Animals Antibodies, Monoclonal Antineoplastic Agents Drug Resistance, Multiple Humans Quinolines Journal Article Review

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T Tsuruo, A Tomida. 1995. Multidrug resistance.. https://doi.org/10.1097/00001813-199504000-00003

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