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PubMed · 7796269

Simulating efficiently the evolution of DNA sequences.

M Schöniger·A von Haeseler
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Abstract

Two menu-driven FORTRAN programs are described that simulate the evolution of DNA sequences in accordance with a user-specified model. This general stochastic model allows for an arbitrary stationary nucleotide composition and any transition-transversion bias during the process of base substitution. In addition, the user may define any hypothetical model tree according to which a family of sequences evolves. The programs suggest the computationally most inexpensive approach to generate nucleotide substitutions. Either reproducible or non-repeatable simulations, depending on the method of initializing the pseudo-random number generator, can be performed. The corresponding options are offered by the interface menu.

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AlgorithmsBase SequenceBiological EvolutionComputer SimulationDNAEvaluation Studies as TopicModels, GeneticPhylogenySoftwareStochastic ProcessesJournal Article

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BibTeXRIS

M Schöniger, A von Haeseler. 1995. Simulating efficiently the evolution of DNA sequences.. https://doi.org/10.1093/bioinformatics%2F11.1.111

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