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PubMed · 7799083

Evaluation of technetium-99m-sestamibi lung uptake: correlation with left ventricular function.

R Giubbini·R Campini·E Milan·O Zoccarato·C Orlandi·P Rossini·P Giannuzzi·G La Canna·M Galli
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Abstract

UNLABELLED: Lung uptake of 201Tl is a reliable marker of left ventricular dysfunction. The goal of our study was to establish whether the evaluation of lung-to-heart uptake ratios (LHR) with 99mTc-sestamibi imaging may provide valuable information. METHODS: We studied 72 male subjects with recent anterior myocardial infarction undergoing 99mTc-sestamibi first-pass ventriculography and SPECT perfusion imaging. A group of 46 gender-matched subjects with low pre-test likelihood of CAD and normal exercise and rest 99mTc-sestamibi perfusion images was used as a control. The lung-to-heart count ratios (LHR) were calculated on planar projections from the sets of SPECT images. RESULTS: Both groups were studied at rest and after a symptom-limited exercise tolerance test. In the control group a significant decrease in LHR was observed during stress (p < 0.001). The infarcted group showed significantly higher LHR values both at rest and at stress. Exercise and rest LHR values did not differ significantly. A positive correlation was observed between LHR values and left ventricular ejection fraction at rest and stress. CONCLUSION: LHR, measured by 99mTc-sestamibi imaging, gives clinically useful information. Both resting and postexercise values are correlated with ejection fraction and should predict left ventricular dysfunction.

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AdultAgedEvaluation Studies as TopicExercise TestHumansLungMaleMiddle AgedMyocardial InfarctionMyocardiumRadionuclide ImagingStroke VolumeTechnetium Tc 99m SestamibiVentricular Dysfunction, LeftClinical TrialControlled Clinical TrialJournal Article

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R Giubbini, R Campini, E Milan, O Zoccarato, C Orlandi, P Rossini, P Giannuzzi, G La Canna, M Galli. 1995. Evaluation of technetium-99m-sestamibi lung uptake: correlation with left ventricular function.. https://pubmed.ncbi.nlm.nih.gov/7799083/

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