A bioactive fullerene peptide.

C Toniolo; A Bianco; M Maggini; G Scorrano; M Prato; M Marastoni; R Tomatis; S Spisani; G Palú; E D Blair

doi:10.1021/jm00052a015

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A bioactive fullerene peptide.

C Toniolo·A Bianco·M Maggini·G Scorrano·M Prato·M Marastoni·R Tomatis·S Spisani·G Palú·E D Blair

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Abstract

The highly hydrophobic C60 (buckminsterfullerene) was water solubilized by covalently linking the synthon 1,2-dihydro-1,2-methanofullerene [60]-61-carboxylic acid to the alpha-amino group of the hydrophilic 4-8 sequence of peptide T, known to display potent human monocyte chemotaxis. The resulting compound, characterized by a variety of analytical techniques, including a UV spectrum in aqueous solution, exhibits remarkable chemotactic potency, comparable to that of the parent pentapeptide. Furthermore, this fullerene-peptide conjugate inhibits, albeit weakly, HIV-1 protease.

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Amino Acid Sequence Chemotaxis, Leukocyte HIV Protease Inhibitors Humans Molecular Sequence Data Monocytes Peptide T Journal Article

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C Toniolo, A Bianco, M Maggini, G Scorrano, M Prato, M Marastoni, R Tomatis, S Spisani, G Palú, E D Blair. 1994-12-23. A bioactive fullerene peptide.. https://doi.org/10.1021/jm00052a015

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