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PubMed · 7803536

Graft-versus-host disease.

D Bron
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Abstract

Combinations of drugs such as methotrexate, cyclosporin A, and prednisone have reduced the incidence of graft-versus-host disease (GVHD) to 20% to 30%. However, GVDH remains a major complication (up to 90%) following allogeneic bone marrow transplantation from unrelated or mismatched donors. GVHD is now understood as a two-step phenomenon: first, the activation of specific cytotoxic T cells and second, the release of several cytokines. Recent treatment modalities, including new immunosuppressors, T-cell depletion, and anticytokine monoclonal antibodies are discussed.

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Acute DiseaseAdolescentAdultBone Marrow TransplantationChildChronic DiseaseClinical Trials as TopicGlucocorticoidsGraft vs Host DiseaseHumansImmunosuppressive AgentsLymphocyte DepletionNeoplasmsSurvival RateT-Lymphocyte SubsetsThalidomideTreatment OutcomeJournal ArticleReview

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BibTeXRIS

D Bron. 1994. Graft-versus-host disease.. https://doi.org/10.1097/00001622-199407000-00006

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