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PubMed · 7813164

[Endogenous anti-analgesic systems].

A Bertolini·R Poggioli·M Bernardi·S Genedani·S Guarini·C Bazzani·R Arletti·A Benelli·E Bertolini·A Balugani
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Abstract

Nociception is of vital importance for the organism, while its inhibition by endogenous opioid systems is usually a sign of surrender. Therefore, it must be assumed that endogenous analgesic systems are balanced, and in fact, under normal conditions, overwhelmed, by teleologically far more important anti-analgesic systems. The two main anti-analgesic systems--i.e., the melanotropinergic and the cholecystokininergic--are here reviewed for their role, not only in nociception, but in a wide variety of vital functions (endocrine, gastrointestinal, ingestive, reproductive, cardiovascular, immune, etc.). Available data strongly suggest that these systems (particularly the melanotropinergic one) play a key role in the overall homeostasis of the body. Moreover, modulation of endogenous anti-analgesic systems may disclose a new, unforeseen approach to the treatment of pain.

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AnalgesiaCholecystokininHumansMelanocyte-Stimulating HormonesPainReceptors, CholecystokininReceptors, Pituitary HormoneJournal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

A Bertolini, R Poggioli, M Bernardi, S Genedani, S Guarini, C Bazzani, R Arletti, A Benelli, E Bertolini, A Balugani. 1994. [Endogenous anti-analgesic systems].. https://pubmed.ncbi.nlm.nih.gov/7813164/

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