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Age-dependent decrease in platelet aggregation in rats.

K Oshima·T Morikawa·M Hagiwara
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Abstract

The degree of platelet aggregation induced by ADP and collagen was examined in platelet-rich plasma from 7- to 90-week-old rats. The aggregation induced by ADP was unchanged at 90 weeks. Collagen-induced aggregation decreased remarkably at 60 and 90 weeks. Therefore, collagen-induced platelet activation is highly age-dependent, with rats of advanced age showing a lower response than younger rats.

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Adenosine DiphosphateAgingAnimalsCollagenMalePlatelet AggregationRatsRats, WistarJournal Article

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K Oshima, T Morikawa, M Hagiwara. 1994. Age-dependent decrease in platelet aggregation in rats.. https://doi.org/10.1248/bpb.17.1124

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