Correlation between computed tomographic brain scan abnormalities and neuropsychological function in children with symptomatic human immunodeficiency virus disease.

P Brouwers; C DeCarli; L Civitello; H Moss; P Wolters; P Pizzo

doi:10.1001/archneur.1995.00540250043011

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Correlation between computed tomographic brain scan abnormalities and neuropsychological function in children with symptomatic human immunodeficiency virus disease.

P Brouwers·C DeCarli·L Civitello·H Moss·P Wolters·P Pizzo

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Abstract

OBJECTIVE: To evaluate the clinical significance of computed tomographic brain scan abnormalities observed in children with symptomatic human immunodeficiency virus disease. PATIENTS: Eighty-seven previously untreated children with symptomatic human immunodeficiency virus type 1 disease. METHODS: General levels of cognitive functioning, obtained from age-appropriate intelligence tests, and social-emotional behavior were correlated with computed tomographic brain scan abnormality ratings. RESULTS: A significant relation between computed tomographic brain scan abnormalities and cognitive dysfunction as well as aberrant behavior was found, which appeared stronger in (younger) vertically infected children compared with transfusion-infected patients. Calcifications, independent from the degree of brain atrophy, were associated with significantly greater delays in neurocognitive development. CONCLUSION: Computed tomographic brain scan abnormalities, even when mild, were of clinical significance, suggesting that human immunodeficiency virus-associated central nervous system compromise is a continuous process and that scans may be helpful at baseline in defining patients at risk and for monitoring them during therapy.

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Brain Brain Diseases Calcinosis Child Child, Preschool Cognition Disorders Female Functional Laterality HIV Infections HIV-1 Humans Infectious Disease Transmission, Vertical Intelligence Tests Male Tomography, X-Ray Computed Journal Article

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P Brouwers, C DeCarli, L Civitello, H Moss, P Wolters, P Pizzo. 1995. Correlation between computed tomographic brain scan abnormalities and neuropsychological function in children with symptomatic human immunodeficiency virus disease.. https://doi.org/10.1001/archneur.1995.00540250043011

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