Immunoconjugates: lessons from animal models.

S Canevari; M Colombatti; M I Colnaghi

doi:10.1093/oxfordjournals.annonc.a058972

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Immunoconjugates: lessons from animal models.

S Canevari·M Colombatti·M I Colnaghi

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Abstract

Monoclonal antibody-mediated cancer therapy has evolved through a challenging chain of problems and solutions. The very limited therapeutic success obtained with unarmed monoclonal antibodies has increased the interest in different antibody-based targeting strategies, and numerous preclinical and even clinical studies with immunoconjugates have now been conducted. We comment here on the messages implicit in a recent report on a doxorubicin-anti-carcinoma antibody conjugate and from several other studies.

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Animals Antibodies, Monoclonal Disease Models, Animal Doxorubicin Immunoconjugates Mice Neoplasms, Experimental Rats Journal Article Research Support, Non-U.S. Gov't Review

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S Canevari, M Colombatti, M I Colnaghi. 1994. Immunoconjugates: lessons from animal models.. https://doi.org/10.1093/oxfordjournals.annonc.a058972

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