Simulating the process of malignant transformation.

E G Luebeck; S H Moolgavkar

doi:10.1016/0025-5564(94)90008-6

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Simulating the process of malignant transformation.

E G Luebeck·S H Moolgavkar

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Abstract

A computationally efficient method for the simulation of carcinogenesis is presented. The underlying model for the process is the two-mutation clonal expansion model with explicit consideration of stochastic growth of malignant tumors. The usual likelihood-based methods of analysis ignore the growth kinetics of malignant tumors. The effect of this oversight on estimation of parameters is explored by simulation.

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Animals Cell Transformation, Neoplastic Humans Likelihood Functions Mathematics Models, Biological Mutation Neoplasms Neoplastic Stem Cells Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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E G Luebeck, S H Moolgavkar. 1994. Simulating the process of malignant transformation.. https://doi.org/10.1016/0025-5564(94)90008-6

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