Microbial adhesins recognizing extracellular matrix macromolecules.

J M Patti; M Höök

doi:10.1016/0955-0674(94)90104-x

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PubMed · 7833055

Microbial adhesins recognizing extracellular matrix macromolecules.

J M Patti·M Höök

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Abstract

Microorganisms express a family of cell-surface adhesins that specifically recognize and bind components of the extracellular matrix. Adhesion of microorganisms to host tissues represents a critical phase in the development of many types of infections. Recent studies have focused on the mechanisms of microbial attachment at a molecular level, including the identification of ligand-binding domains in several cell-surface adhesins from Gram-positive bacteria and the construction of adhesin-deficient isogenic mutants.

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Adhesins, Bacterial Amino Acid Sequence Animals Anti-Bacterial Agents Bacterial Infections Cell Adhesion Collagen Drug Design Extracellular Matrix Fibronectins Humans Molecular Sequence Data Protein Binding Virulence Journal Article Research Support, U.S. Gov't, P.H.S.Review

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J M Patti, M Höök. 1994. Microbial adhesins recognizing extracellular matrix macromolecules.. https://doi.org/10.1016/0955-0674(94)90104-x

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