[Small peptides with antibiotic activity].

E P Kharenko

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PubMed · 7840703

[Small peptides with antibiotic activity].

E P Kharenko

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Abstract

Peptide dKRFdLE showed in vitro stable activity against gram negative bacteria i.e. Escherichia coli and Pseudomonas fluorescens when grown on the minimum glucose-mineral medium. Substitutions of the N- and C-end amino acids in the molecule of the peptide decreased its antibiotic activity. Comparison of the amino acid sequences of the known peptides with antibiotic activity made it possible to conclude that the presence of the doublet of the basic amino acids at the N-end and the doublet of the hydrophobic amino acids in the peptide core is necessary for the antibiotic activity. Possible mechanisms of the antibiotic action of short peptides and the ways for the rational search of new peptide antibiotics are discussed.

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Amino Acid Sequence Anti-Bacterial Agents Escherichia coli Molecular Sequence Data Oligopeptides Pseudomonas fluorescens Journal Article

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E P Kharenko. 1994. [Small peptides with antibiotic activity].. https://pubmed.ncbi.nlm.nih.gov/7840703/

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