How much is a stabilizing bond worth?

K A Sharp; S W Englander

doi:10.1016/0968-0004(94)90051-5

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PubMed · 7846760

How much is a stabilizing bond worth?

K A Sharp·S W Englander

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Abstract

It is commonly supposed that the contribution of a bond to protein or nucleic acid stability is equal to the in situ stability of the bond itself. This is not true for the noncovalent bonds that stabilize molecular folding. In general, a bonding interaction contributes a free energy increment to protein or nucleic acid stability that is larger, an enthalpy increment that is smaller, and entropy and heat capacity increments that are more positive than the corresponding bond parameter.

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Drug Stability Hydrogen Bonding Nucleic Acid Conformation Nucleic Acids Protein Folding Proteins Thermodynamics Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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K A Sharp, S W Englander. 1994. How much is a stabilizing bond worth?. https://doi.org/10.1016/0968-0004(94)90051-5

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