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Modulation of cytokine expression by hypericum extract.

B Thiele·I Brink·M Ploch
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Abstract

The effect of hypericum extract LI 160 on the stimulated cytokine expression was investigated in vitro in a whole blood culture system. Blood samples were taken from five healthy volunteers and four depressive patients. The release of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) was measured quantitatively after an incubation time of 24 hours on microtiter plates. A massive suppression of the interleukin-6 release was found for PHA-stimulated hypericum extract. Possible relations to the antidepressive effects of hypericum extract are discussed.

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Antidepressive AgentsCytokinesDepressionHumansHypericumIn Vitro TechniquesInterleukin-1Interleukin-6PerylenePilot ProjectsPlant ExtractsPlants, MedicinalQuercetinTumor Necrosis Factor-alphaXanthenesJournal Article

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B Thiele, I Brink, M Ploch. 1994. Modulation of cytokine expression by hypericum extract.. https://doi.org/10.1177/089198879400700116

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