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PubMed · 7864038

Chorionic villi sampling: laboratory experience with 4,000 consecutive cases.

B T Wang·W Peng·K T Cheng·S F Chiu·W Ho·Y Khan·M Wittman·J Williams
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Abstract

Experience with 4,000 consecutive CVS cases shows that 1) the combination of both the direct and culture methods greatly reduces false diagnoses and maternal cell contamination; 2) the time interval between the sampling procedure and processing of villus specimens influences the quality of direct preparations; 3) maternal cell contamination (MCC) can be minimized with dissection of CVS specimens. We have compiled a large volume of confined placental mosaicism (CPM) cases to serve as a resource in interpreting mosaic cytogenetic findings. It was noted that, in up to 92% of the mosaic cases, the abnormal cell line was confined to the placenta. The frequency of true chromosomal mosaicism was 0.2%, and is not different from that for amniocentesis.

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Cells, CulturedChorionic Villi SamplingChromosome AberrationsFemaleHumansMaleMitotic IndexMosaicismPregnancyJournal Article

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B T Wang, W Peng, K T Cheng, S F Chiu, W Ho, Y Khan, M Wittman, J Williams. 1994-12-01. Chorionic villi sampling: laboratory experience with 4,000 consecutive cases.. https://doi.org/10.1002/ajmg.1320530402

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