Neuronal cdc2-like kinase.

J Lew; J H Wang

doi:10.1016/s0968-0004(00)88948-3

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Neuronal cdc2-like kinase.

J Lew·J H Wang

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Abstract

Neurofilament proteins and the neuron-specific microtubule-associated protein tau are phosphorylated in vivo at sites conforming to the phosphorylation consensus motif of the cell-cycle-control protein kinase, p34cdc2-cyclin. Abnormalities in the phosphorylation of these proteins are associated with neurodegenerative disorders, such as amylotrophic lateral sclerosis and Alzheimer's disease. A cdc2-like kinase composed of cyclin-dependent kinase 5 (cdk5) and a brain-specific regulatory subunit is proposed to be responsible for the cdc2-like phosphorylation of these neuronal proteins.

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Amino Acid Sequence Animals Molecular Sequence Data Neurons Protein Serine-Threonine Kinases Journal Article Review

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J Lew, J H Wang. 1995. Neuronal cdc2-like kinase.. https://doi.org/10.1016/s0968-0004(00)88948-3

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