Extrathymic intestinal T-cell development: virtual reality?

L Lefrançois; L Puddington

doi:10.1016/0167-5699(95)80065-4

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Extrathymic intestinal T-cell development: virtual reality?

L Lefrançois·L Puddington

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Abstract

Extrathymic T-cell development is a topic of considerable interest and debate, with important implications for the mechanisms of T-cell maturation and repertoire selection. Recent evidence has suggested that intraepithelial T lymphocytes (IELs) of the small intestine can mature and undergo selection in the absence of a thymus. However, IEL precursors are present in the thymus and IEL development is known to be influenced by the thymus. Here, Leo Lefrançois and Lynn Puddington discuss these data and suggest that the differentiation pathway of IEL precursors is dependent on whether or not a thymus is present.

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Animals Cell Differentiation Epithelial Cells Humans Intestine, Small Mice Mice, Nude T-Lymphocytes Thymus Gland Journal Article Research Support, U.S. Gov't, P.H.S.Review

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L Lefrançois, L Puddington. 1995. Extrathymic intestinal T-cell development: virtual reality?. https://doi.org/10.1016/0167-5699(95)80065-4

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