Cdc2 regulatory factors.

T R Coleman; W G Dunphy

doi:10.1016/0955-0674(94)90060-4

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PubMed · 7880537

Cdc2 regulatory factors.

T R Coleman·W G Dunphy

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Abstract

A growing family of kinases and phosphatases controls the activity of the cyclin-dependent kinase cdc2. The past year has seen the identification of the cdk activating kinase as well as considerable elucidation of the cdc25/wee1 regulatory pathways. Both cdc25 and wee1 appear to be regulated by upstream kinase/phosphatase networks. In addition, it is likely that other regulatory mechanisms cooperate with the wee1/cdc25 phosphorylation systems to control the action of cdc2. Together, these elaborate checks and balances ensure that cdc2 triggers mitosis at the appropriate time.

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Animals CDC2 Protein Kinase Cell Cycle Proteins Enzyme Activation Humans Maturation-Promoting Factor Nuclear Proteins Phosphoprotein Phosphatases Protein-Tyrosine Kinases Proteins Schizosaccharomyces pombe Proteins cdc25 Phosphatases Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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T R Coleman, W G Dunphy. 1994. Cdc2 regulatory factors.. https://doi.org/10.1016/0955-0674(94)90060-4

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