PubMed · 7883537
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H Koop. 1995. [Function tests in gastroenterology].. https://pubmed.ncbi.nlm.nih.gov/7883537/
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The bronchopulmonary-foregut malformations (BPFM) are usually sporadic, solitary cystic hamartomas involving conducting airways, arteries, venous drainage, and lung parenchyma. Transitional, compound hamartomas exist, and only their morphology is well-known. Between 1984-1994 we encountered and studied 10 unrelated patients and a stillborn infant with BPFM (out of 24,000 families). Ten were diagnosed in utero and one at birth as having congenital cystic adenomatoid malformation of the lung (CCAML). Postnatally, two diagnoses (20%) were corrected to bronchogenic cyst (BC) and diaphragmatic hernia, respectively. Bilateral lung involvement was present in 1 patient, and in 2 there was a considerable macroscopic regression of the hamartoma. Histologic studies of the six resected CCAML confirmed the diagnosis and implied dysregulated paracrine growth with its cellular and extracellular growth factors, protooncogenes, oncogenes, cytokines, cell-adhesive molecules, and receptors of these regulatory peptides, and their complex interactions as developmental morphogens in time and space.
Although radiation has proven itself valuable in the treatment of a variety of pelvic malignancies, it is not without serious morbidity. This article has outlined the incidence of acute and chronic injury, ways to prevent the occurrence of complications, and the use of new medical and surgical treatments.
The gastrointestinal tract is a complex organ with many functions. Many diseases affect the way in which the gastrointestinal tract performs these functions. The pharmaceutical industry and academia are putting great effort into the development of treatments for these diseases. As a consequence, there is increasing pressure on the clinical pharmacologist and gastroenterologist to develop methods to measure the effects of drugs on the gastrointestinal tract. This article reviews the methods currently available to assess gastrointestinal function; in particular it focuses on motility and sensitivity.