Synthetic peptides as binding-step based catalytic mimics.

E Pérez-Payá; R A Houghten; S E Blondelle

PubMed · 7888710

Synthetic peptides as binding-step based catalytic mimics.

Abstract

Peptides able to adopt an environment-dependent secondary structure represent attractive models for enzyme mimics. An approach to design new synthetic enzyme-like peptides involves the use of binding-step based mimics. The polypeptide melittin, based on its intrinsic ability to bind to phospholipids, was selected as a potential binding-step based catalytic mimic. Synthetic melittin was found to exhibit weak but reproducible phospholipase-like activity. The rate enhancement of the hydrolysis of phospholipids, although far from that of the natural enzyme, was encouraging as a first step in the development of new catalytic peptides.

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Amino Acid Sequence Catalysis Enzymes Melitten Molecular Sequence Data Peptides Phospholipids Protein Structure, Secondary Journal Article Review

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E Pérez-Payá, R A Houghten, S E Blondelle. Synthetic peptides as binding-step based catalytic mimics.. https://pubmed.ncbi.nlm.nih.gov/7888710/

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