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Structure and function of poly(ADP-ribose) polymerase.

G de Murcia·V Schreiber·M Molinete·B Saulier·O Poch·M Masson·C Niedergang·J Ménissier de Murcia
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Abstract

Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genetoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and the function of this abundant and highly conserved enzyme. This article summarizes our present knowledge in this field.

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Amino Acid SequenceAnimalsCatalysisDNAHumansModels, MolecularMolecular Sequence DataNucleic Acid ConformationPoly(ADP-ribose) PolymerasesProtein Structure, TertiaryStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov'tReview

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G de Murcia, V Schreiber, M Molinete, B Saulier, O Poch, M Masson, C Niedergang, J Ménissier de Murcia. 1994. Structure and function of poly(ADP-ribose) polymerase.. https://doi.org/10.1007/bf00928438

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