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Methyl mercury, mercuric chloride, and silver lactate decrease superoxide anion formation and chemotaxis in human polymorphonuclear leucocytes.

N Obel·B Hansen·M M Christensen·S L Nielsen·J Rungby
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Abstract

Cytotoxic effects of mercuric chloride, methyl mercury, and silver lactate on polymorphonuclear leucocytes have been examined by assaying superoxide anion formation capability and chemotaxis of metal-exposed cells. Both superoxide anion formation and chemotaxis were negatively affected by all three metal compounds. Both bacteriotoxic functions were affected in a dose-dependent fashion, the functional deficits were seen at doses not affecting cell viability. Dose-response curves were remarkably similar for all three compounds. The bacteriotoxic capacity of polymorphonuclear leucocytes may be hampered by mercury and silver.

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Cell SurvivalChemotaxis, LeukocyteHumansIn Vitro TechniquesLactatesLactic AcidMercuric ChlorideMethylmercury CompoundsMicroscopy, ElectronN-Formylmethionine Leucyl-PhenylalanineNeutrophilsSuperoxidesTetradecanoylphorbol AcetateJournal ArticleResearch Support, Non-U.S. Gov't

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N Obel, B Hansen, M M Christensen, S L Nielsen, J Rungby. 1993. Methyl mercury, mercuric chloride, and silver lactate decrease superoxide anion formation and chemotaxis in human polymorphonuclear leucocytes.. https://doi.org/10.1177/096032719301200503

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