Control points in early T-cell development.

D I Godfrey; A Zlotnik

doi:10.1016/0167-5699(93)90186-o

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Control points in early T-cell development.

D I Godfrey·A Zlotnik

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Abstract

Intrathymic T-cell differentiation involves the generation, expansion and selection of distinct T-lymphocyte subsets. While positive and negative selection have been a focal point of T-cell development, these events represent the final stages in a complicated sequence of differentiation steps. Here, Dale Godfrey and Albert Zlotnik summarize recent advances in our understanding of early T-cell development and describe five 'control points' that identify key events in this sequence.

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Animals CD4-Positive T-Lymphocytes Cell Differentiation Gene Rearrangement, T-Lymphocyte Humans Lymphocyte Activation Mice Receptors, Antigen, T-Cell, alpha-beta T-Lymphocytes T-Lymphocytes, Regulatory Thymus Gland Journal Article Research Support, Non-U.S. Gov't Review

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D I Godfrey, A Zlotnik. 1993. Control points in early T-cell development.. https://doi.org/10.1016/0167-5699(93)90186-o

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