CD4 negative mice as a model for immunodeficiency.

A Rahemtulla; A Shahinian; T Kundig; R Zinkernagel; T W Mak

doi:10.1098/rstb.1993.0135

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PubMed · 7904347

CD4 negative mice as a model for immunodeficiency.

A Rahemtulla·A Shahinian·T Kundig·R Zinkernagel·T W Mak

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Abstract

CD4 is a co-receptor required for T cell helper functions. A mouse strain without CD4 expression has been generated. These animals, surprisingly have a normal CTL response and reduced, but not absent, humoral responses. A new population of MHC class II restricted CD4-CD8-TcR alpha beta+ T cells has emerged which possess helper function potential. These findings have important implications on disease situations where CD4 cells are decreased or absent.

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Animals Antibody Formation CD4 Antigens CD8 Antigens Disease Models, Animal Immunologic Deficiency Syndromes Lymph Nodes Mice Mice, Mutant Strains Phenotype T-Lymphocyte Subsets T-Lymphocytes T-Lymphocytes, Cytotoxic Thymus Gland Journal Article

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A Rahemtulla, A Shahinian, T Kundig, R Zinkernagel, T W Mak. 1993-10-29. CD4 negative mice as a model for immunodeficiency.. https://doi.org/10.1098/rstb.1993.0135

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