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PubMed · 7906056

Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channels.

A Mastrogiacomo·S M Parsons·G A Zampighi·D J Jenden·J A Umbach·C B Gundersen
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Abstract

Presynaptic calcium channels are key regulators of neurotransmitter release. Oocyte expression studies suggest that cysteine string proteins are essential subunits or modulators of these channels. Subcellular fractionation revealed that cysteine string proteins copurify with synaptic vesicles. An average vesicle had eight protein monomers with both the amino and carboxyl termini detected on the cytoplasmic face. Thus, docked synaptic vesicles may regulate presynaptic calcium channels and neurotransmitter release.

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AnimalsCalcium ChannelsCell FractionationElectric OrganMembrane ProteinsMicroscopy, ElectronMovementNerve Tissue ProteinsNeurotransmitter AgentsPresynaptic TerminalsSynaptic TransmissionSynaptic VesiclesTorpedoJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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A Mastrogiacomo, S M Parsons, G A Zampighi, D J Jenden, J A Umbach, C B Gundersen. 1994-02-18. Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channels.. https://doi.org/10.1126/science.7906056

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