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Poly(A) and translation: development control.

M Wormington
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Abstract

The stage-specific translational control of maternal mRNAs is determined by their differential polyadenylation and deadenylation. In the past year, a growing number of cis-acting elements that both positively and negatively regulate polyadenylation and deadenylation have been delineated. Considerable progress has been made on the biochemical characterization and regulation of trans-acting polyadenylation and deadenylation factors. This review summarizes these advances and their relevance to the roles of polyadenylation and deadenylation in translational control.

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AnimalsBase SequenceBlastocystExoribonucleasesFertilizationFungal ProteinsGene Expression RegulationMiceMolecular Sequence DataOocytesPoly APolynucleotide AdenylyltransferaseProtein BiosynthesisRNA, MessengerRNA-Binding ProteinsXenopusZygotemRNA Cleavage and Polyadenylation FactorsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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M Wormington. 1993. Poly(A) and translation: development control.. https://doi.org/10.1016/0955-0674(93)90075-2

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