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PubMed · 7908145

FGF-2: apical ectodermal ridge growth signal for chick limb development.

J F Fallon·A López·M A Ros·M P Savage·B B Olwin·B K Simandl
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Abstract

The apical ectodermal ridge permits growth and elongation of amniote limb buds; removal causes rapid changes in mesodermal gene expression, patterned cell death, and truncation of the limb. Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development. A bioassay for FGFs demonstrated that FGF-2 was the only detectable FGF in chick limb bud extracts. By distribution and bioactivity, FGF-2 is the prime candidate for the chick limb bud apical ridge growth signal.

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AnimalsBiological AssayCell DeathCell DifferentiationCell LineCell SurvivalChick EmbryoDNA-Binding ProteinsEctodermExtremitiesFibroblast Growth FactorsGene ExpressionGenes, HomeoboxHomeodomain ProteinsHumansMSX1 Transcription FactorMesodermMusclesRecombinant ProteinsTranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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J F Fallon, A López, M A Ros, M P Savage, B B Olwin, B K Simandl. 1994-04-01. FGF-2: apical ectodermal ridge growth signal for chick limb development.. https://doi.org/10.1126/science.7908145

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