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Does HIV disrupt a naturally occurring immune modulation system?

J R Kennedy
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Abstract

An immune modulation complex is proposed which recognizes and is driven by an MHC presented epitope of the CD4 molecule present on the surface of up regulated CD4+ lymphocytes. Immune modulation is affected by both CD4 lymphocyte destruction and impairment of their potential for immune recognition. These two processes are carefully controlled by an idiotypic, anti-idiotypic feedback mechanism. The CD4 tropic area of HIV impersonates some components of that feedback loop resulting in increased CD4 lymphocyte destruction.

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AnimalsCD4 AntigensCD4-Positive T-LymphocytesCoxsackievirus InfectionsFeedbackHIVHIV InfectionsHumansImmunityModels, BiologicalMyocarditisT-Lymphocytes, CytotoxicJournal Article

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J R Kennedy. 1993. Does HIV disrupt a naturally occurring immune modulation system?. https://doi.org/10.1016/0306-9877(93)90123-8

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