Thymocyte lineage commitment: is it instructed or stochastic?

C B Davis; D R Littman

doi:10.1016/0952-7915(94)90100-7

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Thymocyte lineage commitment: is it instructed or stochastic?

C B Davis·D R Littman

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Abstract

Thymocytes co-expressing the CD4 and CD8 co-receptors differentiate into mature T cells that express either CD4 or CD8 and have helper or cytotoxic functions, respectively. Recent studies indicate that commitment to the CD4+ or CD8+ lineages occurs stochastically, but retention of the appropriate co-receptor is required to complete development.

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Animals CD4-Positive T-Lymphocytes CD8 Antigens Cell Differentiation Humans Lymphocyte Specific Protein Tyrosine Kinase p56(lck)Major Histocompatibility Complex Protein-Tyrosine Kinases Receptors, Antigen, T-Cell Signal Transduction Stochastic Processes T-Lymphocytes Thymus Gland Journal Article Research Support, Non-U.S. Gov't Review

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C B Davis, D R Littman. 1994. Thymocyte lineage commitment: is it instructed or stochastic?. https://doi.org/10.1016/0952-7915(94)90100-7

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