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PubMed · 7915638

[Nociceptive modulation during intravenous anesthesia].

E P Vandermeulen·P F White
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Abstract

The surgical stress can be defined as a complex array of neuroendocrine, haemodynamic, metabolic and inflammatory changes following surgical injury. These responses, when excessive, may contribute to increased postoperative morbidity and mortality. Thus a major endpoint of general anaesthesia is to protect the patient against the noxious stress response components. The different classes of anaesthetic or associated drugs are reviewed in this respect: sedative/hypnotics (barbiturates, etomidate, propofol, benzodiazepines), opioids, alpha-2 adrenergic agonists (clonidine), non-steroidal antiinflammatory drugs, intravenous local anaesthetics. Central and peripheral sensitization phenomenons--ie the sympathoadrenal response to surgery--might likely be efficiently attenuated by preemptive analgesia, and/or well-designed computer-guided total intravenous anaesthesia. 119 references complete this review.

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Adrenergic beta-AntagonistsAnesthesia, IntravenousAnestheticsAnesthetics, LocalEtomidateHumansHypnotics and SedativesNarcoticsPain MeasurementStress, PhysiologicalEnglish AbstractJournal ArticleReview

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E P Vandermeulen, P F White. 1994. [Nociceptive modulation during intravenous anesthesia].. https://pubmed.ncbi.nlm.nih.gov/7915638/

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