d-amphetamine conditioned place preference in developing mice: relations with changes in activity and stereotypies.

G Laviola; G Dell'Omo; F Chiarotti; G Bignami

doi:10.1037//0735-7044.108.3.514

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d-amphetamine conditioned place preference in developing mice: relations with changes in activity and stereotypies.

G Laviola·G Dell'Omo·F Chiarotti·G Bignami

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Abstract

Conditioned place preference (CPP) with both visual and tactile cues, hyperactivity, and stereotypies produced by d-amphetamine (1-10 mg/kg ip, single dose) were studied in CD-1 mice at 2, 3, and 4 weeks from birth. CPP was shown from the youngest age onward in female mice and from 3 weeks in male mice. Hyperactivity was much more pronounced in postweanlings (3 and 4 weeks) than in preweanlings. Stereotypies (at 3.3 and 10 mg/kg) occurred from the youngest age and tended to peak at 3 weeks. Stereotypies may indicate a sickness experience or "poor welfare" (G.J. Mason, 1991; A. Wall, R.E. Hinson, E. Schmidt, C. Johnston, & A. Streather, 1990) due to an aversive component of amphetamine's action. Therefore, the delayed development of fully fledged amphetamine CPP, relative to cocaine CPP (G. Laviola, G. Dell'Omo, E. Alleva, & G. Bignami, 1992), may be due to an age-dependent diminution of the positive hedonic value of the former drug by negative effects that are minimal or absent in the case of the latter drug.

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Age Factors Animals Association Learning Choice Behavior Conditioning, Classical Dextroamphetamine Dose-Response Relationship, Drug Female Male Mice Motor Activity Social Environment Stereotyped Behavior Touch Visual Perception Journal Article Research Support, Non-U.S. Gov't

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G Laviola, G Dell'Omo, F Chiarotti, G Bignami. 1994. d-amphetamine conditioned place preference in developing mice: relations with changes in activity and stereotypies.. https://doi.org/10.1037/%2F0735-7044.108.3.514

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