Selection in the expression of functionally distinct B-cell subsets.

N R Klinman

doi:10.1016/0952-7915(94)90121-x

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Selection in the expression of functionally distinct B-cell subsets.

N R Klinman

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Abstract

Although the isolation and characterization of functionally distinct B-cell subsets has been a major preoccupation of immunologists for the past two decades, only recently has it been recognized that the various B-cell subsets may be disparately selected during their development and maturation on the basis of their expressed Ig V regions. Thus, pre-B cells are selected for clonal expansion and maturation by virtue of the amino-acid sequence of their nascent H chains and newly emerging B cells may be selected for longevity and subset distribution on the basis of both clonotype-specific and relatively non-specific interactions of their surface Ig receptors.

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Animals B-Lymphocyte Subsets Cell Differentiation Humans Journal Article Review

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N R Klinman. 1994. Selection in the expression of functionally distinct B-cell subsets.. https://doi.org/10.1016/0952-7915(94)90121-x

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